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Harry Potter (Spells & Charms)Fluffy is an extremely large three-headed dog, apparently loyal to Hagrid.
He is apparently modeled on Cerberus, the three-headed dog who guards the entrance to the Underworld in Greek mythology.
Like any dog, Fluffy has speed and teeth on his side in any physical confrontation; additionally, because the three heads can presumably communicate with each other, one supposes that any attack would be coordinated to come from three directions at once.
Fluffy is also loyal to Hagrid, and apparently a fierce guard dog.
It would appear that Fluffy can be put to sleep by musicA6 Premium Pocket Notebook.