Hiromu Arakawa Fullmetal alchemist (3-in-1 edition), vol. 5

In an alchemical ritual gone wrong, Edward Elric lost his arm and his leg, and his brother Alphonse became nothing but a soul in a suit of armor.

Equipped with mechanical 'auto-mail' limbs, Edward becomes a state alchemist, seeking the one thing that can restore his and his brother's bodies.

the legendary Philosopher's Stone.